They are 2 different things, each with Tylenol. Hard to compare depending on what you mean, some folks respond to one better than the other, some get stomach upset from one and not the other, the pills are different shapes and sizes too. Tylenol vs Advil Tylenol (also known as Acetaminophen) and Advil (also known as ibuprofen) are high quality medicines that provide the basic relief from fever and pain. Works well to relieve pain and fevers. Good for menstrual cramps, toothaches, body aches, and mild arthritis pain. Tylenol Regular Strength (acetaminophen) causes less upset stomach, ulcers, bruising, and bleeding than other pain medications like aspirin and Advil. SHOULD I TAKE TYLENOL, ADVIL OR ASPIRIN? by eugeneyeung. When I work as a pharmacist in a retail pharmacy, I get a lot of questions from customers on which painkiller is best for them. I have been taking 2-3 Ibuprofen daily for a few months now due to lower back pain and headaches. I want to try as much as possible to reduce the risk of stomach ulcers. Feeling like you are about to throw up? Find out the most common causes of nausea and vomiting and get tips to treat your upset stomach. When it comes to reducing fever or relieving pain in children, TYLENOL® has been a reliable, effective medicine recommended by pediatricians for more than 50 years. TYLENOL® Extra Strength Coated Tablets for Adults should be used to temporarily reduce fever and relieve minor aches and pains. Each extra-strength pain relief coated tablet contains 500 milligrams of acetaminophen and can be a safe and effective post-surgery pain relief option when used as directed. Paracetamol, also known as acetaminophen and APAP, is a medication used to treat pain and fever. It is typically used for mild to moderate pain relief. There is mixed evidence for its use to relieve fever in children. Codeine is an opioid pain medication, sometimes called a narcotic. Acetaminophen is a less potent pain reliever that increases the effects of codeine.